GLENDALE, Ariz. — Brock Purdy threw three touchdown passes in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and a receiving score, and the San Francisco 49ers beat the sloppy Arizona Cardinals 41-22 on Sunday.
McCaffrey extended his NFL record with his 17th career game with at least one running touchdown and a touchdown catch. Purdy completed 19 of 26 passes for 200 yards.
Tight end George Kittle caught two touchdown passes.
Arizona lost for the sixth time in seven games. The Cardinals were called for a franchise-record 17 penalties, which was also the most for any team in the NFL this season. They had 11 penalties in the first half — tied for the most before halftime for any team over the past 20 years.
Arizona’s Jacoby Brissett started his fifth straight game for the injured Kyler Murray and completed 47 of 57 passes for 452 yards, two touchdowns and two interceptions. The 47 completions set an NFL record in the regular season.
Michael Wilson caught 15 passes for a career-high 185 yards. Tight end Trey McBride had 115 yards receiving and a touchdown.
The 49ers (7-4) had control from the outset, needing just 16 seconds to take a 7-0 lead. Skyy Moore returned the opening kickoff 98 yards to the Arizona 1, setting up a 1-yard touchdown run by McCaffrey on the next play.
Arizona Cardinals head coach Jonathan Gannon watches from the sideline during the first half of an NFL football game against the San Francisco 49ers in Glendale, Ariz., Sunday, Nov. 16, 2025. Credit: AP/Ross D. Franklin
Purdy returned after being sidelined for six straight games because of the toe injury and was playing his first game since Sept. 28.
He didn’t appear to have much rust: The 25-year-old misfired on his first throw, but then completed three straight passes, including a beautifully-thrown 30-yard touchdown to Kittle for a 13-0 lead with 9:51 left in the first quarter.
For the Cardinals, it was an eerily similar start to last week’s debacle against the Seattle Seahawks, when they fell into a 35-0 hole in the first half before losing 44-22.
Arizona (3-7) had a slightly quicker response against San Francisco, cutting the margin to 13-7 later in the first on Bam Knight’s 6-yard touchdown run, but the good times didn’t last very long. The 49ers pushed ahead 19-7 early in the second quarter when Purdy hit a wide open McCaffrey for a 9-yard score.
Arizona Cardinals quarterback Jacoby Brissett (7) passes against the San Francisco 49ers during the first half of an NFL football game in Glendale, Ariz., Sunday, Nov. 16, 2025. Credit: AP/Ross D. Franklin
Eddy Piñeiro made a 47-yard field goal as time expired in the second quarter to give the 49ers a 25-10 halftime lead. Piñeiro initially had his 62-yard attempt blocked on the previous play, but Arizona’s Calais Campbell was called for a 15-yard penalty for unnecessary roughness, giving the kicker another chance.
The Cardinals continued to make critical errors in the second half. Knight looked like he had a 60-yard touchdown run in the third quarter, but it was called back because of a holding penalty on tight end Pharaoh Brown.
Injuries
49ers: DE Robert Beal Jr. left with a concussion. LB Tatum Bethune (ankle) and defensive back Upton Stout (stinger) left the game in the second quarter. Piñeiro (hamstring) left in the third.
Cardinals: Receiver Marvin Harrison Jr., who had surgery for appendicitis earlier this week, was among seven inactives. RB Emari Demercado (ankle) left the game in the second quarter. CB Garrett Williams (shin) left in the third. RT Kelvin Beachum (groin) left in the fourth.
Up next
49ers: Host Carolina on Monday, Nov. 24.
Cardinals: Host Jacksonville next Sunday.
#Brock #Purdy #throws #TDs #return #toe #injury #49ers #cruise #win #sloppy #Cardinals
